High-Dosage Vitamin E Supplementation and All-Cause Mortality

High-dosage vitamin E supplementation and all-cause mortality.

Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality.

BACKGROUND Experimental models and observational studies suggest that vitamin E supplementation may prevent cardiovascular disease and cancer. However, several trials of high-dosage vitamin E supplementation showed non-statistically significant increases in total mortality. PURPOSE To perform a meta-analysis of the dose-response relationship between vitamin E supplementation and total mortali...

Review: high dose vitamin E supplementation is associated with increased all cause mortality.

Review: vitamin D supplementation decreases all-cause mortality in adults and older individuals.

M e t h o d s Data sources: PubMed, ISI Web of Science (Science Citation Index Expanded), EMBASE/Excerpta Medica, Cochrane Library, and bibliographies of selected studies, reviews, or books (to November 2006). Study selection and assessment: Principal published reports of randomized controlled trials (RCTs) that assessed the effects of vitamin D supplementation (vitamin D2 [ergocalciferol] or v...

Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality.

BACKGROUND & AIMS Results from randomized controlled trials (RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were inconclusive. The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT. METHODS RCT publications on the effect of B vitamin supplementati...